Receptor-Interacting Protein Serine-Threonine Kinases

A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.

Also Known As:

RIP (Receptor Interacting Protein); RIP Serine-Threonine Kinase; Receptor Interacting Protein RIP; Receptor-Interacting Protein Serine-Threonine Kinase 1; Receptor-Interacting Protein Serine-Threonine Kinase 3; Kinase, RIP Serine-Threonine; Kinases, RIP Serine-Threonine; RIP Serine Threonine Kinase; RIP Serine Threonine Kinases; Receptor Interacting Protein Serine Threonine Kinase 1; Receptor Interacting Protein Serine Threonine Kinase 3; Receptor Interacting Protein Serine Threonine Kinases; Serine-Threonine Kinase, RIP; Serine-Threonine Kinases, RIP; RIP Serine-Threonine Kinases

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Receptor-Interacting Protein Serine-Threonine Kinases: 72
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Signal Transducing Adaptor Proteins
      - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins: 44
        Receptor-Interacting Protein Serine-Threonine Kinases: 72
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Receptor-Interacting Protein Serine-Threonine Kinases: 72
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Receptor-Interacting Protein Serine-Threonine Kinases: 72
    - Apoptosis Regulatory Proteins: 2514
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Receptor-Interacting Protein Serine-Threonine Kinases: 72
    - Signal Transducing Adaptor Proteins
      - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins: 44
        Receptor-Interacting Protein Serine-Threonine Kinases: 72
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Receptor-Interacting Protein Serine-Threonine Kinases: 72

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Disease

Drug/Important Bio-Agent (IBA)